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Scientific Evidence

Peer-ReviewedResearch

Explore the comprehensive scientific evidence behind kava's therapeutic benefits, from clinical trials to meta-analyses.

Over 200 peer-reviewed studies validate kava's effectiveness for anxiety, sleep, and stress relief, providing the scientific foundation for traditional Pacific Island wisdom.

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200+
Scientific Studies
50+
Clinical Trials
15+
Meta-Analyses
30+
Years of Research

Research Categories

🧠
Anxiety & Stress
Clinical trials on anxiety reduction
💤
Sleep Quality
Studies on sleep improvement
🔬
Pharmacology
Kavalactone research
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Key ClinicalStudies

Landmark research that established kava's therapeutic benefits

Cochrane Review 2003

Meta-Analysis

Meta-analysis of 11 randomized controlled trials (645 participants) confirming kava's effectiveness for anxiety disorders.

Authors: Pittler MH, Ernst E
Journal: Cochrane Database of Systematic Reviews
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Sarris et al. 2013

Clinical Trial

6-month randomized controlled trial showing 75% reduction in anxiety symptoms with kava extract.

Authors: Sarris J, Stough C, Bousman CA
Journal: Journal of Clinical Psychopharmacology
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Smith & Leiras 2018

Anxiety Treatment Review

Systematic review and analysis demonstrating kava's effectiveness and safety for treating anxiety symptoms across multiple randomized clinical trials.

Authors: Smith K, Leiras C
Journal: Complementary Therapies in Clinical Practice
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Research byCategory

Anxiety & Stress

Clinical trials demonstrating kava's effectiveness for anxiety disorders, generalized anxiety, and stress management.

Double-Blind Placebo Trial

Kinzler et al. (1991) - 58 patients with anxiety neuroses

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Long-term Outpatient Trial

Volz & Kieser (1997) - 25-week placebo-controlled trial

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Benzodiazepine Transition Study

Malsch & Kieser (2001) - Kava following benzodiazepine treatment

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Sleep Quality

Studies showing kava's effects on sleep onset, sleep quality, and REM sleep patterns.

Sleep-Wake Cycle Enhancement

Shinomiya et al. (2005) - Kava-kava extract effects on sleep-disturbed rats

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Effects on Sleep-Wake Cycle

Shinomiya et al. (2005) - Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats

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Sleep Fragmentation Analysis

Emser & Bartylla (1991) - EEG-monitored sleep quality study

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Safety & Pharmacology

Research on kava's safety profile, pharmacokinetics, and mechanism of action.

Hepatotoxicity Review

Teschke et al. (2011) - Comprehensive safety analysis

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Kavalactone Pharmacology

Garrett et al. (2003) - Mechanism of action study

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GABAergic Neurotransmission

Yuan et al. (2002) - Brainstem GABA modulation study

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